What else should I know about ENABLEX?

A1:  ENABLEX is a prescription medicine for the treatment of the symptoms of Overactive Bladder (OAB) in adults. ENABLEX is used to treat the following symptoms:

• leaks or wetting accidents (also called "urinary incontinence");
• having a strong need to go the bathroom right away (also called "urinary urgency");
• having to go to the bathroom too often (also called "urinary frequency").

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A2:  Once-daily ENABLEX is specifically designed to target the muscle that controls the bladder. That helps your bladder work the way it's supposed to, so you can go for a full 24 hours with less bladder interruptions.

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A3:  Like other Overactive Bladder medicines, the most frequently reported side effects of ENABLEX® (darifenacin) were dry mouth, constipation, indigestion, and abdominal pain. The majority of side effects experienced when taking ENABLEX were mild or moderate and most occurred during the first 2 weeks of treatment.

Like all Overactive Bladder medicines, ENABLEX may cause other less common side effects because it belongs to a class of medicines called "anticholinergics." These may include:

• Blurred vision. Use caution while driving or doing dangerous activities until you know how ENABLEX affects you.
• Heat prostration. Heat prostration (due to decreased sweating) can occur when drugs such as ENABLEX are used in a hot environment.

Certain medical conditions can increase your risk of rare side effects. You should talk to your healthcare professional about all your medical history to be aware of any of these risks.

A4:  Before starting ENABLEX, tell your doctor or healthcare professional about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Also tell your doctor or healthcare professional about all of your medical conditions, including if you:

• have any stomach or intestinal problems, or problems with constipation;
• have trouble emptying your bladder or you have a weak urine stream;
• have an eye problem called narrow-angle glaucoma;
• have liver problems;
• are pregnant or planning to become pregnant. It is not known if ENABLEX can harm your unborn baby;
• are breastfeeding. It is not known if ENABLEX passes into breast milk and if it can harm your baby.

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A5:  Take ENABLEX exactly as prescribed. Your doctor will prescribe the dose that is right for you. Your doctor may prescribe the lowest dose if you have certain medical conditions such as liver problems.

You should take ENABLEX once daily with liquid.

• ENABLEX should be swallowed whole and not chewed, divided, or crushed.
• ENABLEX may be taken with or without food.
• If you miss a dose of ENABLEX, begin taking ENABLEX again the next day. Do not take 2 doses of ENABLEX in the same day.
• If you take too much ENABLEX, call your local Poison Control Center or emergency room right away.

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A6:  Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. ENABLEX and certain other medicines can interact with each other, causing side effects. Especially tell your doctor if you take:

• ketoconazole (Nizoral^®) or itraconazole (Sporanox^®), antifungal medicines
• clarithromycin (Biaxin^®), an antibiotic medicine
• ritonivir (Norvir^®) or nelfinavir (Viracept^®), antiviral medicines
• nefazadone (Serzone^®), a depression medicine
• flecainide (Tambocor^TM), an abnormal heartbeat (antiarrhythmia) medicine
• thioridazine (Mellaril^®), a mental disorder (antipsychotic) medicine
• a medicine called a tricyclic antidepressant

Know all the medicines you take. Keep a list of them with you to show your doctor and pharmacist each time you get a medicine.

A9:  No. ENABLEX is approved for treatment of the symptoms of Overactive Bladder in both women and men.

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A10:  Do not take ENABLEX if you:

• have trouble emptying your bladder (also called "urinary retention");
• have delayed or slow emptying of your stomach (also called "gastric retention");
• have an eye problem called "uncontrolled narrow-angle glaucoma";
• are allergic to ENABLEX or to any of its ingredients. A list of ingredients is included in the product's Prescribing Information, which you can read here.

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A11:  Yes. There are no special dosing requirements for older people.